When there's nausea or vomiting with levodopa/carbidopa
If you're experiencing nausea or vomiting with your new dose of levodopa/carbidopa, you're not alone. Almost 1 in 5 people experience nausea when their dose of Sinemet® (levodopa/carbidopa) is first given or is raised.1*
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Share your side effects with your doctor
If you are beginning a new dose of Sinemet® (levodopa/carbidopa) or Sinemet® CR (levodopa/carbidopa) therapy, it is important to talk to your doctor if you are experiencing nausea or vomiting, so your doctor can determine if your medication needs to be adjusted.*
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LODOSYN® (carbidopa) may help
By adding LODOSYN®, your doctor may be able to reduce your dose of levodopa and help reduce levodopa-induced nausea and vomiting.2
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Important Information for Patients
What Is LODOSYN Used For?
LODOSYN® (carbidopa) is used with carbidopa-levodopa or with levodopa alone in the treatment of symptoms of Parkinson's disease. It is for patients who need additional carbidopa or need a daily dose of carbidopa and/or levodopa that is different than the amounts contained in other carbidopa and/or levodopa medications.

LODOSYN may allow your doctor to prescribe lower doses of levodopa to control your Parkinson's disease symptoms. A lower dose of levodopa may reduce the side effects of nausea and vomiting and may also help smooth out your body's response to levodopa.

If you have frequent "off" time while on levodopa, you may not benefit from the addition of carbidopa. Carbidopa has not been shown to improve the efficacy of levodopa in treating the symptoms of Parkinson's disease.
Who Should Not Take LODOSYN?
  • Patients who are allergic to any of its ingredients.
  • Patients taking certain types of monoamine oxidase inhibitors (MAOI) (usually used in the treatment of depression).
  • Patients with an eye disease called narrow-angle glaucoma.
Be sure to speak with your doctor about any medical conditions you have before starting LODOSYN.
How Is LODOSYN Taken?
LODOSYN must be used with another medication that contains levodopa because it does not treat the symptoms of Parkinson's disease when used alone. Levodopa and LODOSYN must be taken at the same time. Do not make any changes to how and when you take LODOSYN without contacting your doctor. Be sure to follow your doctor's instructions when you start taking LODOSYN along with your levodopa. You will need to wait at least 12 hours after your last dose of levodopa alone before starting levodopa plus LODOSYN. Sometimes a “wearing off” effect happens before your next dose of LODOSYN. Tell your doctor about this if it poses a problem to your lifestyle.
What Side Effects Are Seen With LODOSYN?
When LODOSYN is taken with levodopa or carbidopa-levodopa medications, the most common side effects have included uncontrolled body movements (known as dyskinesias), and nausea.

Occasionally, a dark color (such as red, brown or black) may appear in your saliva, urine or sweat after taking LODOSYN and levodopa. This does not appear to affect your health, but may color your clothes.

Tell your doctor if you change your diet to foods that are high in protein, as this may affect the absorption of LODOSYN.

There is the possibility that you could unexpectedly fall asleep while taking LODOSYN or levodopa medications. Be careful when driving or operating machinery, and if you experience sleepiness or fall asleep unexpectedly, do not drive or operate machinery.

Tell your doctor if you experience new or increased urges to gamble, sexual urges or other intense urges while taking LODOSYN or levodopa.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1-800-FDA-1088. You may also contact Valeant Customer Service at 1-800-556-1937.
What Should I Tell My Doctor Before Starting LODOSYN?
Tell your doctor about all medications you are taking, including vitamins and herbal supplements.

There have been rare reports of serious side effects involving the nervous system (the body's network of nerve cells) when doses of LODOSYN or levodopa alone are changed or stopped suddenly, especially in patients taking certain medications for schizophrenia, bipolar disorder or other mental disorders.

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References:
1. Marsden CD, Parkes JD, Rees JE. A year's comparison of treatment of patients with Parkinson's disease with levodopa combined with carbidopa versus treatment with levodopa alone. Lancet. 1973;2(7844):1459-1462.
2. LODOSYN (carbidopa) [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2006.

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