When there's nausea or vomiting with levodopa/carbidopa
If you're experiencing nausea or vomiting with your new dose of levodopa/carbidopa, you're not alone. Almost 1 in 5 people experience nausea when their dose of Sinemet® (levodopa/carbidopa) is first given or is raised.1*
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Share your side effects with your doctor
If you are beginning a new dose of Sinemet® (levodopa/carbidopa) or Sinemet® CR (levodopa/carbidopa) therapy, it is important to talk to your doctor if you are experiencing nausea or vomiting, so your doctor can determine if your medication needs to be adjusted.*
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LODOSYN® (carbidopa) may help
By adding LODOSYN®, your doctor may be able to reduce your dose of levodopa and help reduce levodopa-induced nausea and vomiting.2
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Important Information for Patients
What Is LODOSYN Used For?
LODOSYN® (carbidopa) is used with SINEMET® (carbidopa-levodopa) or with levodopa alone in the treatment of symptoms of Parkinson's disease. It is for patients who need additional carbidopa or need a daily dose of carbidopa and/or levodopa that is different than the amounts contained in SINEMET.
How Can LODOSYN Help Me?
LODOSYN may allow your doctor to prescribe lower doses of levodopa to control your Parkinson's disease symptoms. A lower dose of levodopa may reduce the side effects of nausea and vomiting and may also help smooth out your body's response to levodopa.

If you have frequent "off" time while on levodopa, you may not benefit from the addition of carbidopa. Carbidopa has not been shown to improve the efficacy of levodopa in treating the symptoms of Parkinson's disease.

LODOSYN does not reduce other side effects of levodopa besides nausea and vomiting.
Who Should Not Take LODOSYN?
  • Patients who are allergic to any of its ingredients.
  • Patients taking certain types of monoamine oxidase inhibitors (MAOI) (usually used in the treatment of depression).
  • Patients with undiagnosed skin conditions or a history of skin cancer.
  • Patients with an eye disease called narrow-angle glaucoma.
Be sure to speak with your doctor about any medical conditions you have before starting LODOSYN.
How Is LODOSYN Taken?
LODOSYN must be used with SINEMET or another product that contains levodopa because it does not treat the symptoms of Parkinson's disease when used alone. Levodopa and LODOSYN must be taken at the same time. Be sure to follow your doctor's instructions when you start taking LODOSYN along with your levodopa. You will need to wait at least 12 hours after your last dose of levodopa alone before starting levodopa plus LODOSYN.
What Side Effects Are Seen With LODOSYN?
Taking LODOSYN along with a lower dose of levodopa may increase uncontrolled body movements (dyskinesia) or make these symptoms occur sooner than with levodopa alone. If this happens, your doctor may need to adjust your dose of levodopa.

When LODOSYN is taken with levodopa or carbidopa-levodopa combination products, the most common side effects have included uncontrolled body movements and nausea. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1-800-FDA-1088. You may also contact Valeant Customer Service at 1-800-556-1937.
What Should I Tell My Doctor Before Starting LODOSYN?
Tell your doctor if you have had a peptic ulcer (a painful stomach disorder), because LODOSYN or levodopa alone can cause bleeding in your digestive system, a serious condition that requires emergency treatment.

There have been rare reports of serious side effects involving the nervous system (the body's network of nerve cells) when doses of LODOSYN or levodopa alone are changed or stopped suddenly, especially in patients taking certain medications for schizophrenia, bipolar disorder or other mental disorders. Make sure you tell your doctor about any medications you are taking.

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References:
1. Marsden CD, Parkes JD, Rees JE. A year's comparison of treatment of patients with Parkinson's disease with levodopa combined with carbidopa versus treatment with levodopa alone. Lancet. 1973;2(7844):1459-1462.
2. LODOSYN (carbidopa) [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2006.

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